The Wilderness Society works with numerous conservation organizations in South Carolina, including:

South Carolina Forest Watch
Founded in 1986, South Carolina Forest Watch is a grassroots conservation group working to protect and preserve the outstanding beauty and priceless natural heritage of South Carolina's public forestlands.

Chattooga Conservancy
The mission of Chattooga Conservancy is to protect, promote and restore the natural ecological integrity of the Chattooga River watershed ecosystem and to ensure the viability of native species in harmony with the need for a healthy human environment. It also seeks to help communities practice good stewardship on public and private lands.

Sierra Club
Sierra Club-Foothills Chapter focuses on Sumter National Forest and Jocassee Gorge issues.